A Hypertension-Associated tRNA Ala Mutation Alters tRNA Metabolism and Mitochondrial Function
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چکیده
منابع مشابه
A Hypertension-Associated tRNAAla Mutation Alters tRNA Metabolism and Mitochondrial Function
In this report, we investigated the pathophysiology of a novel hypertension-associated mitochondrial tRNA(Ala) 5655A → G (m.5655A → G) mutation. The destabilization of a highly conserved base pairing (A1-U72) at the aminoacyl acceptor stem by an m.5655A → G mutation altered the tRNA(Ala) function. An in vitro processing analysis showed that the m.5655A → G mutation reduced the efficiency of tRN...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2016
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00199-16